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Mariko Harada-Shiba Selected Research

Blood Component Removal (Apheresis)

12/2021The Japanese Society for Apheresis clinical practice guideline for therapeutic apheresis.
11/2021Switching from lipoprotein apheresis to evolocumab in FH siblings on hemodialysis: case reports and discussion.
8/2019Familial Hypercholesterolemia and Lipoprotein Apheresis.
4/2019Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study.
2/2019Discontinuation of LDL apheresis with evolocumab in an FH patient with a duplication of exon 2-6 in the LDLR gene.
10/2017LDL apheresis in Japan.
7/2017Toward an international consensus-Integrating lipoprotein apheresis and new lipid-lowering drugs.
4/2017Efficacy and Safety of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia.
1/2017VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body.
11/2016Lipoprotein apheresis is essential for managing pregnancies in patients with homozygous familial hypercholesterolemia: Seven case series and discussion.
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Mariko Harada-Shiba Research Topics

Disease

37Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
08/2022 - 12/2008
21Atherosclerosis
06/2022 - 06/2003
19Cardiovascular Diseases (Cardiovascular Disease)
08/2022 - 01/2012
15Homozygous Familial Hypercholesterolemia
06/2022 - 08/2003
14Coronary Artery Disease (Coronary Atherosclerosis)
08/2022 - 07/2010
12Xanthomatosis (Xanthoma)
06/2022 - 06/2003
8Inborn Genetic Diseases (Disease, Hereditary)
06/2022 - 01/2012
7Dyslipidemias (Dyslipidemia)
06/2022 - 01/2012
6Hyperlipoproteinemia Type III (Broad Beta Disease)
06/2022 - 06/2003
6Hypercholesterolemia
01/2018 - 06/2003
4Acute Coronary Syndrome
12/2021 - 01/2017
4Stroke (Strokes)
12/2021 - 04/2015
4Inflammation (Inflammations)
01/2020 - 03/2010
4Ischemia
04/2015 - 02/2004
3Diabetes Mellitus
12/2022 - 06/2019
3Hypertension (High Blood Pressure)
11/2022 - 08/2021
3Hypertriglyceridemia
10/2022 - 06/2008
3Coronary Disease (Coronary Heart Disease)
01/2019 - 09/2006
3Neoplasms (Cancer)
01/2018 - 12/2012
2Carotid Artery Diseases
06/2022 - 01/2017
2Type 2 Diabetes Mellitus (MODY)
03/2022 - 01/2018
2Myocardial Infarction
12/2021 - 02/2007
2Hyperuricemia
11/2021 - 01/2020
2Hemorrhage
10/2021 - 01/2017
2Anemia
10/2021 - 07/2021
2Atherosclerotic Plaque (Atheroma)
01/2019 - 03/2017
2Body Weight (Weight, Body)
01/2019 - 05/2018
2Necrosis
01/2019 - 02/2004
2Brain Injuries (Brain Injury)
01/2018 - 04/2015
2Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
01/2018 - 01/2016
2Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain)
01/2016 - 04/2015
2Hypoxia (Hypoxemia)
04/2015 - 01/2014
2Breast Neoplasms (Breast Cancer)
10/2013 - 12/2012
2Neoplasm Metastasis (Metastasis)
10/2013 - 12/2012
2Pulmonary Hypertension
07/2009 - 08/2003
1Overweight
11/2022
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/2022
1Chronic Disease (Chronic Diseases)
06/2022
1Platelet Glycoprotein IV Deficiency
04/2022
1Collagen Diseases (Collagen Disease)
12/2021

Drug/Important Bio-Agent (IBA)

41oxidized low density lipoproteinIBA
06/2022 - 08/2003
30LDL CholesterolIBA
11/2022 - 06/2008
20LipidsIBA
08/2022 - 05/2006
19LDL Lipoproteins (beta Lipoproteins)IBA
06/2022 - 08/2003
16LDL Receptors (LDL Receptor)IBA
03/2022 - 06/2003
13Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2022 - 07/2010
12Lipoproteins (Lipoprotein)IBA
08/2022 - 05/2006
7HDL CholesterolIBA
11/2022 - 06/2008
7ApolipoproteinsIBA
08/2022 - 01/2013
7CholesterolIBA
03/2022 - 08/2003
6Pharmaceutical PreparationsIBA
05/2022 - 04/2015
5BMS201038IBA
06/2022 - 04/2017
5Proprotein Convertase 9IBA
01/2021 - 01/2013
5Proteins (Proteins, Gene)FDA Link
01/2017 - 09/2006
5Small Interfering RNA (siRNA)IBA
04/2014 - 11/2009
4HDL LipoproteinsIBA
08/2021 - 01/2012
4Apolipoproteins B (ApoB)IBA
07/2021 - 01/2013
4alirocumabIBA
01/2020 - 12/2015
3Triglycerides (Triacylglycerol)IBA
11/2022 - 01/2012
3Biomarkers (Surrogate Marker)IBA
06/2022 - 01/2016
3SubtilisinIBA
10/2019 - 01/2015
3Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA
10/2019 - 01/2015
3Therapeutic UsesIBA
08/2019 - 04/2015
3Apolipoproteins E (ApoE)IBA
04/2019 - 01/2013
3Atorvastatin (Lipitor)FDA Link
01/2019 - 08/2003
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2017 - 12/2012
3Ezetimibe (Zetia)FDA Link
06/2017 - 05/2006
3CeramidesIBA
01/2013 - 09/2006
2AcidsIBA
04/2022 - 02/2010
2Glucagon-Like Peptide-1 Receptor AgonistsIBA
03/2022 - 01/2018
2omega-Chloroacetophenone (Mace)IBA
12/2021 - 01/2017
2Uric Acid (Urate)IBA
11/2021 - 01/2020
2VitaminsIBA
10/2021 - 01/2019
2EnzymesIBA
09/2021 - 07/2021
2Monoclonal AntibodiesIBA
12/2020 - 12/2015
2CytokinesIBA
04/2019 - 06/2012
2microsomal triglyceride transfer proteinIBA
01/2019 - 07/2017
2Conditioned Culture MediaIBA
01/2019 - 01/2014
2SonazoidIBA
01/2019 - 01/2018
2pitavastatin (itavastatin)FDA Link
05/2018 - 01/2016
2Nucleic AcidsIBA
12/2017 - 09/2012
2Antisense OligonucleotidesIBA
12/2017 - 09/2016
2Dextran SulfateIBA
01/2017 - 11/2016
2Vascular Endothelial Growth Factor CIBA
10/2013 - 12/2012
2MonocrotalineIBA
07/2009 - 08/2003
2AdrenomedullinIBA
07/2009 - 02/2004
1AutoantibodiesIBA
10/2022
1Lipoprotein(a)IBA
08/2022
1Apolipoprotein A-I (Apolipoprotein A1)IBA
06/2022
1Adenosine Triphosphate (ATP)IBA
04/2022
1CD36 AntigensIBA
04/2022

Therapy/Procedure

21Therapeutics
12/2021 - 08/2003
15Blood Component Removal (Apheresis)
12/2021 - 08/2003
3Transplantation
01/2014 - 08/2003
2Renal Dialysis (Hemodialysis)
11/2021 - 07/2021
2Fat-Restricted Diet (Diet, Fat Restricted)
04/2019 - 01/2019
2Coronary Artery Bypass (Coronary Artery Bypass Surgery)
01/2018 - 01/2013
2Intravenous Administration
01/2018 - 01/2016
2Drug Therapy (Chemotherapy)
07/2017 - 04/2017
2Injections
10/2013 - 12/2012